Although potential desensitization treatments have emerged for peanut allergy, these have not been developed for other legumes and most tree nuts, and desensitization to peanut has not proven to have an effect on legume cross-sensitization.Īnaphylaxis Cross-reactivity Cross-sensitization Legumes Peanut Pollen-food syndrome Tree nuts.Ĭopyright © 2018 American Academy of Allergy, Asthma & Immunology. Molecular diagnostic testing may be a future tool to help parse out the aforementioned patterns, but oral food challenges are still the gold standard for accurate diagnosis. Issues of cross-sensitization may exist between peanut and certain tree nuts, as well as among tree nuts though such patterns do not always result in clinically relevant allergy. Many vegetables have also been identified as being cross-reactive with latex proteins. Among legumes, the most common patterns of clinical cross-reactivity are between peanut and lupine, peanut and soy, as well as chickpea and lentil, though this is highly dependent on geography and prevalence of these foods in the diet. What is latex-fruit syndrome The association between latex sensitivity and food allergy is often referred to as the latex-fruit syndrome. Legume allergens belong to the Fabaceae family and encompass the cupin, prolamin, PR-10, and lipid transfer protein families, which mediate cross-sensitization including that between peanut and tree nut. Peanut-allergic individuals can be both cosensitized and coallergic to such items, requiring foresight when eliciting a clinical history of a reaction, in the diagnostic evaluation of such allergies, and in the counseling of patients as to food avoidances after a diagnosis is made. Peanut is an allergenic legume that can cross-react with other plant-based foods, notably other legumes and tree nuts.
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